Article
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
Nature cell biology - 1 Aug 2015
Liu Huayang, Tang Xing, Srivastava Arunima, Pécot Thierry, Daniel Piotr, Hemmelgarn Benjamin, Reyes Stephan, Fackler Nicholas, Bajwa Amneet, Kladney Raleigh, Koivisto Christopher, Chen Zhong, Wang Qianben, Huang Kun, Machiraju Raghu, Sáenz-Robles Maria Teresa, Cantalupo Paul, Pipas James M, Leone Gustavo
Abstract excerpt
Robust mechanisms to control cell proliferation have evolved to maintain the integrity of organ architecture. Here, we investigated how two critical proliferative pathways, Myc and E2f, are integrated to control cell cycles in normal and Rb-deficient cells using a murine intestinal model. We show that Myc and E2f1-3 have little impact on normal G1-S transitions. Instead, they synergistically control an S-G2...
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