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Article

Phenotypic Characterization of Targeted Knockdown of Cyclin-Dependent Kinases in the Intestinal Epithelial Cells.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2020

Lu Shuyan, Sung Tae, Amaro Marina, Hirakawa Brad, Jessen Bart, Hu Wenyue

Abstract excerpt

Cyclin-dependent kinases (CDKs) are serine/threonine kinases that regulate cell cycle and have been vigorously pursued as druggable targets for cancer. There are over 20 members of the CDK family. Given their structural similarity, selective inhibition by small molecules has been elusive. In addition, collateral damage to highly proliferative normal cells by CDK inhibitors remains a safety concern. Intestinal...

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PMID: 32556214
DOI: 10.1093/toxsci/kfaa092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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