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Article

A functional role for Smad7 in sustaining colon cancer cell growth and survival

20 Feb 2014

Abstract excerpt

Initially identified as an inhibitor of transforming growth factor (TGF)-β mainly owing to its ability to bind TGF-β receptor type I and abrogate TGF-β-driven signaling, Smad7 can interact with additional intracellular proteins and regulate TGF-β-independent pathways, thus having a key role in the control of neoplastic processes in various organs. Genome-wide association studies have shown that common alleles of...

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PMID: 24556688
DOI: 10.1038/cddis.2014.49

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