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Article

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.

Nature protocols - 1 Jan 2009

Kumar Prateek, Henikoff Steven, Ng Pauline C

Abstract excerpt

The effect of genetic mutation on phenotype is of significant interest in genetics. The type of genetic mutation that causes a single amino acid substitution (AAS) in a protein sequence is called a non-synonymous single nucleotide polymorphism (nsSNP). An nsSNP could potentially affect the function of the protein, subsequently altering the carrier's phenotype. This protocol describes the use of the 'Sorting...

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PMID: 19561590
DOI: 10.1038/nprot.2009.86

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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