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Article

Identification of deleterious non-synonymous single nucleotide polymorphisms using sequence-derived information.

BMC bioinformatics - 27 Jun 2008

Hu Jing, Yan Changhui

Abstract excerpt

BACKGROUND: As the number of non-synonymous single nucleotide polymorphisms (nsSNPs), also known as single amino acid polymorphisms (SAPs), increases rapidly, computational methods that can distinguish disease-causing SAPs from neutral SAPs are needed. Many methods have been developed to distinguish disease-causing SAPs based on both structural and sequence features of the mutation point. One limitation of these...

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PMID: 18588693
DOI: 10.1186/1471-2105-9-297
PMCID: PMC2446391

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MCC

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