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Article

SIFT missense predictions for genomes.

Nature protocols - 1 Jan 2016

Vaser Robert, Adusumalli Swarnaseetha, Leng Sim Ngak, Sikic Mile, Ng Pauline C

Abstract excerpt

The SIFT (sorting intolerant from tolerant) algorithm helps bridge the gap between mutations and phenotypic variations by predicting whether an amino acid substitution is deleterious. SIFT has been used in disease, mutation and genetic studies, and a protocol for its use has been previously published with Nature Protocols. This updated protocol describes SIFT 4G (SIFT for genomes), which is a faster version of...

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Identifiers

PMID: 26633127
DOI: 10.1038/nprot.2015.123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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