Article
In silico searching for disease-associated functional DNA variants.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Sethumadhavan Rao, Doss C George Priya, Rajasekaran R
Abstract excerpt
Experimental analyses of disease-associated DNA variants have provided significant insights into the functional implications of sequence variation. However, such experiment-based approaches for identifying functional DNA variants from a pool with a large number of neutral variants are challenging. Computational biology has the opportunity to play an important role in the identification of functional DNA variants...
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