Article
In silico searching for disease-associated functional DNA variants.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Sethumadhavan Rao, Doss C George Priya, Rajasekaran R
Abstract excerpt
Experimental analyses of disease-associated DNA variants have provided significant insights into the functional implications of sequence variation. However, such experiment-based approaches for identifying functional DNA variants from a pool with a large number of neutral variants are challenging. Computational biology has the opportunity to play an important role in the identification of functional DNA variants...
Topics
- Computational Biology
- Data Mining
- Databases, Genetic
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Polymorphism, Single Nucleotide
- Software