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Article

SIFT web server: predicting effects of amino acid substitutions on proteins.

Nucleic acids research - 1 Jul 2012

Sim Ngak-Leng, Kumar Prateek, Hu Jing, Henikoff Steven, Schneider Georg, Ng Pauline C

Abstract excerpt

The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants. Since its release, SIFT has become one of the standard tools for characterizing missense variation. We have updated SIFT's genome-wide prediction tool since our last publication in...

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PMID: 22689647
DOI: 10.1093/nar/gks539
PMCID: PMC3394338

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