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Article

Predicting deleterious amino acid substitutions.

Genome research - 1 May 2001

Ng P C, Henikoff S

Abstract excerpt

Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis projects. Each amino acid substitution potentially affects protein function. We have constructed a tool that uses sequence homology to predict whether a substitution affects protein function. SIFT, which sorts intolerant from tolerant substitutions, classifies substitutions as tolerated or...

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Identifiers

PMID: 11337480
DOI: 10.1101/gr.176601
PMCID: PMC311071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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