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Article

Deleterious nonsynonymous single nucleotide polymorphisms in human solute carriers: the first comparison of three prediction methods.

European journal of drug metabolism and pharmacokinetics - 1 Mar 2013

Hao Da-Cheng, Xiao Bing, Xiang Ying, Dong Xue-Wei, Xiao Pei-Gen

Abstract excerpt

Abundant nsSNPs have been found in genes coding for human solute carrier (SLC) transporters, but there is little known about the relationship between the genotype and phenotype of nsSNPs in these membrane proteins. It is unknown which prediction method is better suited for the prediction of nonneutral nsSNPs of SLC transporters. We have identified 2,958 validated nsSNPs in human SLC family members 1-47 from the...

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PMID: 22555822
DOI: 10.1007/s13318-012-0095-8

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