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Computational prediction of the effects of non-synonymous single nucleotide polymorphisms in human DNA repair genes.

Neuroscience - 14 Apr 2007

Nakken S, Alseth I, Rognes T

Abstract excerpt

Non-synonymous single nucleotide polymorphisms (nsSNPs) represent common genetic variation that alters encoded amino acids in proteins. All nsSNPs may potentially affect the structure or function of expressed proteins and could therefore have an impact on complex diseases. In an effort to evaluate the phenotypic effect of all known nsSNPs in human DNA repair genes, we have characterized each polymorphism in terms...

Topics

Computational Biology
DNA Damage
DNA Repair
DNA Repair Enzymes
Databases, Genetic
Gene Expression Profiling
Genome, Human
Humans
Mutation, Missense
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17055652
DOI: 10.1016/j.neuroscience.2006.09.004

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