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Article

Predicting the effects of amino acid substitutions on protein function.

Annual review of genomics and human genetics - 1 Jan 2006

Ng Pauline C, Henikoff Steven

Abstract excerpt

Nonsynonymous single nucleotide polymorphisms (nsSNPs) are coding variants that introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect protein function, they are believed to have the largest impact on human health compared with SNPs in other regions of the genome. Therefore, it is important to distinguish those nsSNPs that affect protein function from those that are functionally...

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PMID: 16824020
DOI: 10.1146/annurev.genom.7.080505.115630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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