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Article

A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.

The Journal of biological chemistry - 21 Aug 2009

Kohli Rahul M, Abrams Shaun R, Gajula Kiran S, Maul Robert W, Gearhart Patricia J, Stivers James T

Abstract excerpt

Enzymes of the AID/APOBEC family, characterized by the targeted deamination of cytosine to generate uracil within DNA, mediate numerous critical immune responses. One family member, activation-induced cytidine deaminase (AID), selectively introduces uracil into antibody variable and switch regions, promoting antibody diversity through somatic hypermutation or class switching. Other family members, including...

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Identifiers

PMID: 19561087
DOI: 10.1074/jbc.M109.025536
PMCID: PMC2755697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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