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Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesviruses

13 Dec 2018

Abstract excerpt

The human gamma-herpesviruses, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, establish lifelong latency in B cells and are associated with multiple malignancies. Virus-host coevolution often drive changes in both host immunity and in the viral genome. We consider one host immune mechanism, the activation-induced deaminase (AID)/APOBEC family of cytidine deaminases, that induces mutations in...

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PMID: 30792902
DOI: 10.1093/ve/vey040

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