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Article

Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients.

Medical oncology (Northwood, London, England) - 1 Jan 2008

Taja-Chayeb Lucia, Vidal-Millán Silvia, Gutiérrez Olga, Ostrosky-Wegman Patricia, Dueñas-González Alfonso, Candelaria Myrna

Abstract excerpt

Polymorphisms at the thiopurine S-methyltransferase coding gene (TPMT) determine enzyme activity and consequently, the development of toxicity secondary to thiopurines. Methods A total of 108 DNA samples from volunteer donors and 39 from patients with acute lymphoblastic leukemia (ALL) were analyzed. Genomic DNA from peripheral blood leukocytes was isolated by standard methods. TPMT gene fragments were amplified...

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Source

Identifiers

PMID: 18188716
DOI: 10.1007/s12032-007-9002-6

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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