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Article

[Phenotype and genotype of thiopurine methyltransferase in Chilean individuals].

Revista medica de Chile - 1 Jul 2012

Jorquera Andrés, Solari Sandra, Vollrath Valeska, Guerra Irene, Chianale José, Cofré Colomba, Kalergis Alexis, Ibáñez Patricio, Bueno Susan, Alvarez-Lobos Manuel

Abstract excerpt

BACKGROUND: Thiopurines (azathioprine and 6-mercaptopurine) are highly effective medications but with potential adverse effects. Thiopurine methyltransferase (TMPT) is the key enzyme in their pharmacokinetics and is genetically regulated. A low activity of TPMT is associated with myelotoxicity. The genotype and enzyme activity can vary by ethnicity. AIM: To study the activity and genotype of TPMT in a group of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23282701
DOI: 10.4067/S0034-98872012000700009

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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