Article
[Frequency of thiopurine S-methyltransferase alleles in different ethnic groups living in Spain].
Medicina clinica - 25 Mar 2006
Corominas Hector, Domènech Montserrat, del Río Elisabeth, Gich Ignasi, Domingo Pere, Baiget Montserrat
Abstract excerpt
BACKGROUND AND OBJECTIVE: Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine drugs regulating their cytotoxicity and clinical response. TPMT activity is inherited as an autosomal recessive trait and several mutations in the TPMT gene have been identified which correlate with a low activity phenotype. A variable number of tandem repeat within the TPMT promoter has been reported to modulate the levels of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.