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Article

[Frequency of thiopurine S-methyltransferase alleles in different ethnic groups living in Spain].

Medicina clinica - 25 Mar 2006

Corominas Hector, Domènech Montserrat, del Río Elisabeth, Gich Ignasi, Domingo Pere, Baiget Montserrat

Abstract excerpt

BACKGROUND AND OBJECTIVE: Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine drugs regulating their cytotoxicity and clinical response. TPMT activity is inherited as an autosomal recessive trait and several mutations in the TPMT gene have been identified which correlate with a low activ...

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Identifiers

PMID: 16595084
DOI: 10.1157/13086124

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16595084-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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