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Article

Thiopurine methyltransferase polymorphisms in a Brazilian population.

The pharmacogenomics journal - 1 Jan 2003

Boson W L, Romano-Silva M A, Correa H, Falcão R P, Teixeira-Vidigal P V, De Marco L

Abstract excerpt

Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Low-activity phenotypes are correlated with several mutations in the TPMT gene. Polymorphisms of TPMT have been reported for Caucasians, African-Americans and Asians. Since ethnic differences have been demonstrated worldwide, it remains to be elucidated in Brazil. The Brazilian population is the result of five centuries of...

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Identifiers

PMID: 12815366
DOI: 10.1038/sj.tpj.6500175

Genes

TPMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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