Article
[Genetic polymorphism of the thiopurine S-methyltransferase of healthy Han Chinese].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Apr 2003
Zhang Jian-Ping, Guan Yong-Yuan, Wu Jue-Heng, Jiang Wen-Qi, Huang Min
Abstract excerpt
BACKGROUND & OBJECTIVE: Several mutations in the thiopurine S-methyltransferase(TPMT) gene have been identified to correlate with a low activity or deficiency phenotype. The distribution of TPMT activity in Chinese and Caucasian populations is different, and the molecular basis has not yet to be determined. This study was designed to investigate the type and frequency of four kinds of mutant TPMT alleles of...
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