Article
Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms.
Transplantation - 27 Jun 2009
Girnita Diana M, Webber Steven A, Brooks Maria M, Ferrell Robert, Girnita Alin L, Burckart Gilbert J, Chinnock Richard, Canter Charles, Addonizio Linda, Bernstein Daniel, Kirklin James K, Naftel David, Zeevi Adriana
Abstract excerpt
BACKGROUND: Granzyme B has been associated with allograft rejection in solid organ transplantation. Single nucleotide polymorphisms (SNPs) in the granzyme B gene might impact its expression. The aims of this study were (1) to establish the frequency of two granzyme B SNPs (A-295G; Q-55R) in pediatric heart transplant (PHTx) recipients and (2) to determine their phenotypic expression in healthy individuals....
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