Article
Genetic variation in recipient B-cell activating factor modulates phenotype of GVHD.
Blood - 28 Jul 2011
Clark William B, Brown-Gentry Kristin D, Crawford Dana C, Fan Kang-Hsien, Snavely Jennifer, Chen Heidi, Savani Bipin N, Kassim Adetola, Greer John P, Schuening Friedrich G, Engelhardt Brian G, Jagasia Madan H
Abstract excerpt
B-cell activating factor (BAFF) single nucleotide polymorphisms (SNPs) are associated with autoimmune diseases. Because patients with classic and overlap chronic GVHD (cGVHD) have features of autoimmune diseases, we studied the association of recipient and/or donor BAFF SNPs with the phenotype of GVHD after allogeneic stem cell transplantation. Twenty tagSNPs of the BAFF gene were genotyped in 164 recipient/donor...
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