Article

GZMB and PRF1 mRNA expression and donor genotypes and their associations with post-transplant complications in allogeneic hematopoietic stem cell transplant recipients

2025-05-08

Abstract excerpt

<title>Abstract</title> <p>Graft-versus-host disease (GvHD) and cytomegalovirus (CMV) infection are serious complications after allogeneic hematopoietic stem cell transplantation (HSCT) and NK cells are involved in their pathogenesis. As granzyme B (GzmB) and perforin are markers of cytotoxicity, we examined polymorphism and expression of GzmB and perforin genes in the context of HSCT outcome. A number of 247 pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fe4f61f-e4f9-5520-abf9-ae3431fe2447
DOI: 10.21203/rs.3.rs-6556505/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GZMB and PRF1 mRNA expression and donor genotypes and their associations with post-transplant complications in allogeneic hematopoietic stem cell transplant recipientsDOI 10.21203/rs.3.rs-6556505/v1Read

Association between granzyme B and perforin I polymorphisms and allograft outcomes in Hispanic kidney transplant recipients.Semantic proximity Read

Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.Semantic proximity Read

Genomic polymorphisms of the innate immune system and allogeneic stem cell transplantation.Semantic proximity Read

Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) and clinical outcomes post-allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis.Semantic proximity Read

Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease.Semantic proximity Read

Graft-versus-host disease biomarkers: omics and personalized medicine.Semantic proximity Read

Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.Semantic proximity Read

Polymorphisms of cytokine and innate immunity genes and GVHD.Semantic proximity Read

Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.Semantic proximity Read

Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples.Semantic proximity Read

Impact of inflammatory cytokine gene polymorphisms on developing acute graft-versus-host disease in children undergoing allogeneic hematopoietic stem cell transplantation.Semantic proximity Read

QPY/RAH haplotypes of the GZMB gene are associated with natural killer cell cytotoxicity.Semantic proximity Read