Article
Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.
Transplantation - 27 Dec 2006
Girnita Diana M, Webber Steven A, Ferrell Robert, Burckart Gilbert J, Brooks Maria M, McDade Kevin K, Chinnock Richard, Canter Charles, Addonizio Linda, Bernstein Daniel, Kirklin James K, Girnita Alin L, Zeevi Adriana
Abstract excerpt
BACKGROUND: Allograft failure in African-Americans remains higher than in Caucasians. Single nucleotide polymorphisms (SNPs) have been associated with altered allograft outcomes. METHODS: In this multi-center study we compared SNP frequencies in 364 pediatric heart recipients from three ethnic/racial groups: Caucasian (n = 243), African-American (n = 39), and Hispanic (n = 82). The target genes were: tumor...
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