Article
The major human and mouse granzymes are structurally and functionally divergent.
The Journal of cell biology - 20 Nov 2006
Kaiserman Dion, Bird Catherina H, Sun Jiuru, Matthews Antony, Ung Kheng, Whisstock James C, Thompson Philip E, Trapani Joseph A, Bird Phillip I
Abstract excerpt
Approximately 2% of mammalian genes encode proteases. Comparative genomics reveals that those involved in immunity and reproduction show the most interspecies diversity and evidence of positive selection during evolution. This is particularly true of granzymes, the cytotoxic proteases of natural killer cells and CD8+ T cells. There are 5 granzyme genes in humans and 10 in mice, and it is suggested that granzymes...
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