Article
Genetic variations in T-cell activation and effector pathways modulate alloimmune responses after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies.
Haematologica - 1 Dec 2012
Xiao Haowen, Luo Yi, Lai Xiaoyu, Fu Shan, Shi Jimin, Tan Yamin, He Jingsong, Xie Wanzhuo, Zheng Weiyan, Wang Li-Mengmeng, Zhang Lifei, Liu Lizhen, Ye Xiujin, Yu Xiaohong, Cai Zhen, Lin Maofang, Huang He
Abstract excerpt
BACKGROUND: Recently, several important polymorphisms have been identified in T-cell activation and effector pathway genes and have been reported to be associated with inter-patient variability in alloimmune responses. The present study was designed to assess the impact of these genetic variations on the outcomes of allogeneic hematopoietic stem cell transplantation. DESIGN AND METHODS: We first investigated ten...
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