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Article

Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.

PloS one - 1 Jan 2011

Espinoza Luis J, Takami Akiyoshi, Nakata Katsuya, Yamada Kayoko, Onizuka Makoto, Kawase Takakazu, Sao Hiroshi, Akiyama Hideki, Miyamura Koichi, Okamoto Shinichiro, Inoue Masami, Fukuda Takahiro, Morishima Yasuo, Kodera Yoshihisa, Nakao Shinji

Abstract excerpt

Serine protease granzyme B plays important roles in infections, autoimmunity, transplant rejection, and antitumor immunity. A triple-mutated granzyme B variant that encodes three amino substitutions (Q48R, P88A, and Y245H) has been reported to have altered biological functions. In the polymorphis...

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Identifiers

PMID: 21886827
DOI: 10.1371/journal.pone.0023827
PMCID: PMC3160316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21886827-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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