Article
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
McIlroy Dorian, Cartron Pierre-François, Tuffery Pierre, Dudoit Yasmine, Samri Assia, Autran Brigitte, Vallette François M, Debré Patrice, Theodorou Ioannis
Abstract excerpt
Granzyme B (GzmB) is a serine protease involved in many pathologies, including viral infections, autoimmunity, transplant rejection, and antitumor immunity. To measure the extent of genetic variation in GzmB, we screened the GzmB gene for polymorphisms and defined a frequently represented triple-mutated GzmB allele. In this variant, three amino acids of the mature protein Q(48)P(88)Y(245) are mutated to...
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