Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catalytic roles of CYP2C9 and its variants (CYP2C92 and CYP2C93) in lornoxicam 5'-hydroxylation.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2004

Iida Izumi, Miyata Atsunori, Arai Masayuki, Hirota Mitsuyo, Akimoto Masayuki, Higuchi Shohei, Kobayashi Kaoru, Chiba Kan

Abstract excerpt

The effects of allelic variants of CYP2C9 (CYP2C9*2 and CYP2C9*3) on lornoxicam 5'-hydroxylation were studied using the corresponding variant protein expressed in baculovirus-infected insect cells and human liver microsomes of known genotypes of CYP2C9. The results of the baculovirus expression system showed that CYP2C9.3 gives higher K(m) and lower V(max) values for lornoxicam 5'-hydroxylation than does...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Baculoviridae

Share to Catalysis

Share to Cytochrome P-450 CYP2C9

Share to Hydroxylation

Share to Insecta

Share to Microsomes, Liver

Source

Identifiers

PMID: 14709614
DOI: 10.1124/dmd.32.1.7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catalytic roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in lornoxicam 5'-hydroxylation.PMID 14709614Read ↗

Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans.Semantic proximity Read ↗

Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype.Semantic proximity Read ↗

In vitro assessment of 36 CYP2C9 allelic isoforms found in the Chinese population on the metabolism of glimepiride.Semantic proximity Read ↗

Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects.Semantic proximity Read ↗

In vitro functional characterization of 37 CYP2C9 allelic isoforms found in Chinese Han population.Semantic proximity Read ↗

Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam.Semantic proximity Read ↗

Effect of the CYP2C9*3 allele on lornoxicam metabolism.Semantic proximity Read ↗

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.Semantic proximity Read ↗

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans.Semantic proximity Read ↗

[Impact of cytochrome P450 CYP2C9 variant allele CYP2C9 * 3 on the pharmacokinetics of glibenclamide and lornoxicam in Chinese subjects].Semantic proximity Read ↗

Site-directed mutation studies of human liver cytochrome P -450 isoenzymes in the CYP2C subfamilySemantic proximity Read ↗

Comparison of enzyme kinetic parameters obtained in vitro for reactions mediated by human CYP2C enzymes including major CYP2C9 variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.