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Article

Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism.

Drug design, development and therapy - 1 Jan 2020

Tang Peng-Fei, Zheng Xiang, Hu Xiao-Xia, Yang Cheng-Cheng, Chen Zhe, Qian Jian-Chang, Cai Jian-Ping, Hu Guo-Xin

Abstract excerpt

AIM: We aimed to systematically examine the effects of enzymatic activity of 38 human CYP2C9 alleles and 21 human CYP3A4 alleles, including wild-type CYP2C9.1 and CYP3A4.1, which contain the 24 CYP2C9 novel alleles (*36-*60) and 6 CYP3A4 novel alleles (*28-*34) newly found in the Chinese population, on sildenafil metabolism through in vitro experiment. METHODS: The recombinant cytochrome P450 alleles protein of...

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Identifiers

PMID: 33262574
DOI: 10.2147/DDDT.S268796
PMCID: PMC7699448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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