Article
GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010
Xuei Xiaoling, Flury-Wetherill Leah, Dick Danielle, Goate Alison, Tischfield Jay, Nurnberger John, Schuckit Marc, Kramer John, Kuperman Sam, Hesselbrock Victor, Porjesz Bernice, Foroud Tatiana, Edenberg Howard J
Abstract excerpt
The genes encoding several GABA-A receptor subunits, including GABRA2, have been associated with alcoholism, suggesting that variations in gaba signaling contribute to risk. Therefore, as part of a comprehensive evaluation of the GABA receptor genes, we evaluated the potential association of GABRR1 and GABRR2, which encode the rho1 and rho2 subunits of the pentameric GABA-A/GABA-C receptors. GABRR1 and GABRR2 lie...
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