Article
Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort.
International journal of molecular sciences - 15 Jun 2026
Rojas-Pirela Maura, Gómez Lesmes Sandra Patricia, Salete-Granado Daniel, Llorente Hernán, Pérez Nieto María-Ángeles, Novo-Veleiro Ignacio, Cieza-Borrella Clara, Pastor Isabel, Fernández-Mateos Javier, Inés Revuelta Sandra M, Chamorro Antonio-Javier, Laso Francisco-Javier, González-Sarmiento Rogelio, Marcos Miguel
Abstract excerpt
Alcohol use disorder (AUD) is influenced by genetic factors that affect key neurobiological systems, including dopaminergic and GABAergic pathways, which regulate neurobehavioral functions and are modulated by brain-derived neurotrophic factor (BDNF). Variations in these genes contribute to individual vulnerability to AUD. In this study, we investigated single-nucleotide polymorphisms (SNPs) and haplotypic...
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