Article
Allelic and haplotypic association of GABRA2 with alcohol dependence.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Aug 2004
Covault Jonathan, Gelernter Joel, Hesselbrock Victor, Nellissery Maggie, Kranzler Henry R
Abstract excerpt
Alcohol dependence is a highly prevalent disorder that is associated with serious morbidity and mortality. Because the GABAA neurotransmitter receptor is an important mediator for several behavioral effects of alcohol, genes encoding GABA-related proteins are functional candidates to influence risk of alcohol dependence. Two genome-wide scans showed linkage of alcohol dependence to a region on chromosome 4p,...
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