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Article

GABRB2, a key player in neuropsychiatric disorders and beyond.

Gene - 30 Jan 2022

Barki Manel, Xue Hong

Abstract excerpt

The GABA receptors represent the main inhibitory system in the central nervous system that ensure synaptogenesis, neurogenesis, and the regulation of neuronal plasticity and learning. GABAA receptors are pentameric in structure and belong to the Cys-loop superfamily. The GABRB2 gene, located on chromosome 5q34, encodes the β2 subunit that combines with the α and γ subunits to form the major subtype of GABAA...

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Identifiers

PMID: 34673206
DOI: 10.1016/j.gene.2021.146021

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