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Article

Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.

American journal of human genetics - 1 Apr 2004

Edenberg Howard J, Dick Danielle M, Xuei Xiaoling, Tian Huijun, Almasy Laura, Bauer Lance O, Crowe Raymond R, Goate Alison, Hesselbrock Victor, Jones Kevin, Kwon Jennifer, Li Ting-Kai, Nurnberger John I, O'Connor Sean J, Reich Theodore, Rice John, Schuckit Marc A, Porjesz Bernice, Foroud Tatiana, Begleiter Henri

Abstract excerpt

Alcoholism is a complex disease with both genetic and environmental risk factors. To identify genes that affect the risk for alcoholism, we systematically ascertained and carefully assessed individuals in families with multiple alcoholics. Linkage and association analyses suggested that a region of chromosome 4p contained genes affecting a quantitative endophenotype, brain oscillations in the beta frequency range...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Markers

Share to Genetic Variation

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Share to Polymorphism, Single Nucleotide

Share to Receptors, GABA-A

Source

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Identifiers

PMID: 15024690
DOI: 10.1086/383283
PMCID: PMC1181946

Genes

GABRA2
GABRA4
GABRB1
GABRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.PMID 15024690Read ↗

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