Article
Genetic variation in GABRβ1 and the risk for developing alcohol dependence.
Psychiatric genetics - 1 Jun 2017
McCabe William A, Way Michael J, Ruparelia Kush, Knapp Susanne, Ali M Adam, Anstee Quentin M, Thomas Howard C, McQuillin Andrew, Morgan Marsha Y
Abstract excerpt
Associations between the γ-aminobutyric acid type-A receptors (GABAA) and alcohol dependence risk have been reported, although the receptor subunit driving the association is unclear. Recent work in mice has highlighted a possible role for variants in the Gabr β1 subunit (Gabrβ1) in alcohol dependence risk, although this gene does not contain any common nonsynonymous variants in humans. However, the GABAA...
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