Article
GABAA receptor polymorphisms in alcohol use disorder in the GWAS era.
Psychopharmacology - 1 Jun 2018
Koulentaki Mairi, Kouroumalis Elias
Abstract excerpt
Alcohol use disorder (AUD) is a chronic, relapsing, neuro-psychiatric illness of high prevalence and with a serious public health impact worldwide. It is complex and polygenic, with a heritability of about 50%, and influenced by environmental causal heterogeneity. Risk factors associated with its etiology have a genetic component. GABA (γ-aminobutyric acid) is a major inhibitory neurotransmitter in mammalian...
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