Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague.

PloS one - 16 Jun 2009

Zauberman Ayelet, Tidhar Avital, Levy Yinon, Bar-Haim Erez, Halperin Gideon, Flashner Yehuda, Cohen Sara, Shafferman Avigdor, Mamroud Emanuelle

Abstract excerpt

An important virulence strategy evolved by bacterial pathogens to overcome host defenses is the modulation of host cell death. Previous observations have indicated that Yersinia pestis, the causative agent of plague disease, exhibits restricted capacity to induce cell death in macrophages due to ineffective translocation of the type III secretion effector YopJ, as opposed to the readily translocated YopP, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrophages

Share to Plague

Share to Vaccines

Share to Virulence

Share to Yersinia enterocolitica

Share to Yersinia pestis

Source

Open in PubMed Open full text

Identifiers

PMID: 19529770
DOI: 10.1371/journal.pone.0005938
PMCID: PMC2691952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague.PMID 19529770Read ↗

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.Semantic proximity Read ↗

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence.Semantic proximity Read ↗

Yersinia pestis YopJ suppresses tumor necrosis factor alpha induction and contributes to apoptosis of immune cells in the lymph node but is not required for virulence in a rat model of bubonic plague.Semantic proximity Read ↗

Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.Semantic proximity Read ↗

YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected].Semantic proximity Read ↗

Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence.Semantic proximity Read ↗

D27-pLpxL, an Avirulent Strain of Yersinia pestis , Primes T Cells That Protect against Pneumonic PlagueSemantic proximity Read ↗

Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice.Semantic proximity Read ↗

The cytotoxic protein YopE of Yersinia obstructs the primary host defence.Semantic proximity Read ↗

Intramuscular Immunization of Mice with a Live-Attenuated Triple Mutant of Yersinia pestis CO92 Induces Robust Humoral and Cell-Mediated Immunity To Completely Protect Animals against Pneumonic Plague.Semantic proximity Read ↗

YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia.Semantic proximity Read ↗

Virulence plasmid-encoded YopK is essential for Yersinia pseudotuberculosis to cause systemic infection in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.