Article
Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.
Infection and immunity - 1 Sept 2018
Palace Samantha G, Proulx Megan K, Szabady Rose L, Goguen Jon D
Abstract excerpt
Virulence of Yersinia pestis in mammals requires the type III secretion system, which delivers seven effector proteins into the cytoplasm of host cells to undermine immune responses. All seven of these effectors are conserved across Y. pestis strains, but three, YopJ, YopT, and YpkA, are apparently dispensable for virulence. Some degree of functional redundancy between effector proteins would explain both...
Topics
- Animals
- Apoptosis
- Bacterial Proteins
- Coculture Techniques
- Cysteine Endopeptidases
- Gain of Function Mutation
- Humans
- Macrophages
- Mice
- Mice, Inbred C57BL
- Neutrophils
- Phenotype
- Protein Serine-Threonine Kinases
- Type III Secretion Systems