Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.

Infection and immunity - 1 Sept 2018

Palace Samantha G, Proulx Megan K, Szabady Rose L, Goguen Jon D

Abstract excerpt

Virulence of Yersinia pestis in mammals requires the type III secretion system, which delivers seven effector proteins into the cytoplasm of host cells to undermine immune responses. All seven of these effectors are conserved across Y. pestis strains, but three, YopJ, YopT, and YpkA, are apparently dispensable for virulence. Some degree of functional redundancy between effector proteins would explain both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gain of Function Mutation

Share to Macrophages

Share to Neutrophils

Share to Protein Serine-Threonine Kinases

Share to Type III Secretion Systems

Share to Yersinia pestis

Source

Open in PubMed Open full text

Identifiers

PMID: 29891548
DOI: 10.1128/IAI.00318-18
PMCID: PMC6105907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.PMID 29891548Read ↗

Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence.Semantic proximity Read ↗

Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on VirulenceSemantic proximity Read ↗

Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.Semantic proximity Read ↗

Chromosomally-Encoded Yersinia pestis Type III Secretion Effector Proteins Promote Infection in Cells and in MiceSemantic proximity Read ↗

Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague.Semantic proximity Read ↗

Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells.Semantic proximity Read ↗

Heightened Virulence of Yersinia Is Associated with Decreased Function of the YopJ Protein.Semantic proximity Read ↗

Yersinia pseudotuberculosis YopD mutants that genetically separate effector protein translocation from host membrane disruption.Semantic proximity Read ↗

The <i>Yersinia pestis</i> effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunitySemantic proximity Read ↗

Identification of a Novel Salmonella Type III Effector by Quantitative Secretome Profiling.Semantic proximity Read ↗

Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence.Semantic proximity Read ↗

Heightened virulence of <i>Yersinia</i> is associated with decreased function of the YopJ proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.