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Article

Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence.

Infection and immunity - 1 Oct 2010

Felek Suleyman, Tsang Tiffany M, Krukonis Eric S

Abstract excerpt

To establish a successful infection, Yersinia pestis requires the delivery of cytotoxic Yops to host cells. Yops inhibit phagocytosis, block cytokine responses, and induce apoptosis of macrophages. The Y. pestis adhesin Ail facilitates Yop translocation and is required for full virulence in mice. To determine the contributions of other adhesins to Yop delivery, we deleted five known adhesins of Y. pestis. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20679446
DOI: 10.1128/IAI.00167-10
PMCID: PMC2950350

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Source receipt: pubmed, retrieved 7 Sept 2026.

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