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Article

YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia.

BMC immunology - 16 Jun 2010

Cantwell Angelene M, Bubeck Sarah S, Dube Peter H

Abstract excerpt

BACKGROUND: Yersinia pestis is the causative agent of pneumonic plague; recently, we and others reported that during the first 24-36 hours after pulmonary infection with Y. pestis pro-inflammatory cytokine expression is undetectable in lung tissues. RESULTS: Here, we report that, intranasal infection of mice with CO92 delta yopH mutant results in an early pro-inflammatory response in the lungs characterized by an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20565713
DOI: 10.1186/1471-2172-11-29
PMCID: PMC2894752

Genes

TNF

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