Article
Intramuscular Immunization of Mice with a Live-Attenuated Triple Mutant of Yersinia pestis CO92 Induces Robust Humoral and Cell-Mediated Immunity To Completely Protect Animals against Pneumonic Plague.
Clinical and vaccine immunology : CVI - 1 Dec 2015
Tiner Bethany L, Sha Jian, Ponnusamy Duraisamy, Baze Wallace B, Fitts Eric C, Popov Vsevolod L, van Lier Christina J, Erova Tatiana E, Chopra Ashok K
Abstract excerpt
Earlier, we showed that the Δlpp ΔmsbB Δail triple mutant of Yersinia pestis CO92 with deleted genes encoding Braun lipoprotein (Lpp), an acyltransferase (MsbB), and the attachment invasion locus (Ail), respectively, was avirulent in a mouse model of pneumonic plague. In this study, we further evaluated the immunogenic potential of the Δlpp ΔmsbB Δail triple mutant and its derivative by different routes of...
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