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D27-pLpxL, an Avirulent Strain of Yersinia pestis , Primes T Cells That Protect against Pneumonic Plague

21 Jul 2009

Abstract excerpt

Vaccinating with live, conditionally attenuated, pigmentation (Pgm)-deficient Yersinia pestis primes T cells that protect mice against pneumonic plague. However, Pgm-deficient strains are not considered safe for human use because they retain substantial virulence in animal models. Y. pestis strains engineered to express Escherichia coli LpxL are avirulent owing to constitutive production of lipopolysaccharide...

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PMID: 19620344
DOI: 10.1128/iai.00273-09

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