Article
The cytotoxic protein YopE of Yersinia obstructs the primary host defence.
Molecular microbiology - 1 Apr 1990
Rosqvist R, Forsberg A, Rimpiläinen M, Bergman T, Wolf-Watz H
Abstract excerpt
It has previously been shown that the plasmid-encoded YopE protein of Yersinia pseudotuberculosis is a virulence determinant. In this study, HeLa cells, macrophages and mice were used as different model systems to determine the actual role of YopE in the virulence process. The YopE protein mediates a cytotoxic response on a confluent layer of HeLa cells. A prerequisite of this activity is that the pathogen binds...
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