Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence.

Abstract excerpt

Numerous microbial pathogens modulate or interfere with cell death pathways in cultured cells. However, the precise role of host cell death during in vivo infection remains poorly understood. Macrophages infected by pathogenic species of Yersinia typically undergo an apoptotic cell death. This is due to the activity of a Type III secreted effector protein, designated YopJ in Y. pseudotuberculosis and Y. pestis,...

Topics

• Animals
• Apoptosis
• Bacterial Proteins
• Bone Marrow Cells
• Cells, Cultured
• Cytotoxicity Tests, Immunologic
• Dendritic Cells
• Disease Models, Animal
• Female
• Host-Pathogen Interactions
• Macrophages