Article
Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation.
Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2012
Price Paul A, Jin Jianping, Goldman William E
Abstract excerpt
Disease progression of primary pneumonic plague is biphasic, consisting of a preinflammatory and a proinflammatory phase. During the long preinflammatory phase, bacteria replicate to high levels, seemingly uninhibited by normal pulmonary defenses. In a coinfection model of pneumonic plague, it appears that Yersinia pestis quickly creates a localized, dominant anti-inflammatory state that allows for the survival...
Topics
- Animals
- Genetic Complementation Test
- Mice
- Mice, Inbred C57BL
- Mutation
- Plague
- Respiratory Tract Infections
- Subcutaneous Tissue
- Time Factors
- Virulence
- Yersinia pestis