Article
YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected].
PloS one - 1 Jan 2013
Zauberman Ayelet, Flashner Yehuda, Levy Yinon, Vagima Yaron, Tidhar Avital, Cohen Ofer, Bar-Haim Erez, Gur David, Aftalion Moshe, Halperin Gideon, Shafferman Avigdor, Mamroud Emanuelle
Abstract excerpt
Plague, initiated by Yersinia pestis infection, is a rapidly progressing disease with a high mortality rate if not quickly treated. The existence of antibiotic-resistant Y. pestis strains emphasizes the need for the development of novel countermeasures against plague. We previously reported the generation of a recombinant Y. pestis strain (Kim53ΔJ+P) that over-expresses Y. enterocolitica YopP. When this strain...
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