Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice.

Abstract excerpt

Pathogenic Yersinia cause a systemic infection in mice that is dependent on the presence of a large plasmid encoding a number of secreted virulence proteins called Yops. We previously demonstrated that a plasmid-encoded Yop, YopJ, was essential for inducing apoptosis in cultured macrophages. Here...

Topics

• Animals
• Apoptosis
• Female
• Lymphoid Tissue
• Mice
• Mice, Inbred BALB C
• Mutation
• Virulence
• Yersinia
• Yersinia Infections