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Article

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

1 Jan 2009

Abstract excerpt

Despite a comprehensive mapping of the Parkinson's disease (PD)-related mRNA and protein leucine-rich repeat kinase 2 (LRRK2) in the mammalian brain, its physiological function in healthy individuals remains enigmatic. Based on its structural features and kinase properties, LRRK2 may interact with other proteins involved in signalling pathways. Here, we show a widespread LRRK2 mRNA and/or protein expression in...

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PMID: 19523245
DOI: 10.1186/1750-1326-4-25

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