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Article

How Parkinson's Disease-Linked LRRK2 Mutations Affect Different CNS Cell Types.

Journal of Parkinson's disease - 1 Jan 2024

Bailey Hannah M, Cookson Mark R

Abstract excerpt

LRRK2 is a relatively common genetic risk factor for Parkinson's disease (PD), with six coding variants known to cause familial PD. Non-coding variation at the same locus is also associated with sporadic PD. LRRK2 plays a role in many different intracellular signaling cascades including those involved in endolysosomal function, cytoskeletal dynamics, and Ca2+ homeostasis. PD-causing LRRK2 mutations cause...

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Identifiers

PMID: 38905056
DOI: 10.3233/JPD-230432
PMCID: PMC11492021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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