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The parkinson's disease-associated LRRK2 mutation R1441G inhibits neuronal differentiation of neural stem cells.

Stem cells and development - 15 Sept 2013

Bahnassawy Lamia'a, Nicklas Sarah, Palm Thomas, Menzl Ingeborg, Birzele Fabian, Gillardon Frank, Schwamborn Jens C

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause familial as well as sporadic Parkinson's disease (PD) that is characterized by an age-dependent degeneration of dopaminergic neurons. LRRK2 is strongly expressed in neural stem cells (NSCs), but still the exact molecular function of LRRK2 in these cells remains unknown. By performing a systemic analysis of the gene expression profile of...

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PMID: 23600457
DOI: 10.1089/scd.2013.0163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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