Article
The parkinson's disease-associated LRRK2 mutation R1441G inhibits neuronal differentiation of neural stem cells.
Stem cells and development - 15 Sept 2013
Bahnassawy Lamia'a, Nicklas Sarah, Palm Thomas, Menzl Ingeborg, Birzele Fabian, Gillardon Frank, Schwamborn Jens C
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause familial as well as sporadic Parkinson's disease (PD) that is characterized by an age-dependent degeneration of dopaminergic neurons. LRRK2 is strongly expressed in neural stem cells (NSCs), but still the exact molecular function of...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- Cell Survival
- Cell- and Tissue-Based Therapy
- Cells, Cultured
- Down-Regulation
- Gene Expression Profiling
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- MicroRNAs
- Mitochondria
- Mutation
- Neural Stem Cells
- Oxidation-Reduction